Principal investigator: Prof. Cecilia Gelfi – CNR-Institute of Molecular Bioimmaging and Physiology.
Hypoxia-induced changes in rat organs (brain, heart, liver, skeletal muscle, blood) exposed to 10 and 6.5% oxygen (corresponding to 5000 m and 8000 m altitude), will be investigated. This project will provide a list of protein changes induced by hypoxia in different organs, a mechanism for hypoxia adaptation and knowledge for treatment of hypoxia in a number of human disease such as stroke, cancer and respiratory disease. The project began in 2007 and aims ultimately to improve our understanding of the mechanisms for hypoxia adaptation, so as to transfer this information to human pathologies at sea level. Proteomic investigations will be performed on rats exposed to hypoxia.